Immune evasion genes from filarial nematodes

Immunological genomics of Brugia malayi: filarial genes implicated in immune evasion and protective immunity.

Filarial nematodes are metazoan parasites with genome sizes of> 100 million base pairs, probably encoding 15 000-20 000 genes. Within this considerable gene complement, it seems likely that filariae have evolved a spectrum of immune evasion products which underpin their ability to live for many years within the human host. Moreover, no suitable vaccine currently exists for human filarial diseas...

Recombination in wolbachia endosymbionts of filarial nematodes?

Biopesticides from Entomopathogenic Nematodes

Karimipour Fard H. and Saeidi K. 2019. Biopesticides from entomopathogenic nematodes   Plant Pathology Science 8(1): 60-73. DOI: 10.2982/PPS.8.1.60.   In the recant decade, biopesticides with entomopathogenic nematodes (EPNs) have been developed with using different methods and materials. But the production of such biopesticides has always accompanied by some limitations such as low quality o...

Gender-Associated Genes in Filarial Nematodes Are Important for Reproduction and Potential Intervention Targets

BACKGROUND A better understanding of reproductive processes in parasitic nematodes may lead to development of new anthelmintics and control strategies for combating disabling and disfiguring neglected tropical diseases such as lymphatic filariasis and onchocerciasis. Transcriptomatic analysis has provided important new insights into mechanisms of reproduction and development in other invertebra...

Deletion of Parasite Immune Modulatory Sequences Combined with Immune Activating Signals Enhances Vaccine Mediated Protection against Filarial Nematodes

BACKGROUND Filarial nematodes are tissue-dwelling parasites that can be killed by Th2-driven immune effectors, but that have evolved to withstand immune attack and establish chronic infections by suppressing host immunity. As a consequence, the efficacy of a vaccine against filariasis may depend on its capacity to counter parasite-driven immunomodulation. METHODOLOGY AND PRINCIPAL FINDINGS We...